Uber was using Node for a good portion of their backend services back when I worked there (2016-2017). I’m not sure what they’re doing now, but when I left there was a project to move a lot of stuff to Go.

IIRC, the performance of Node was ok but clearly worse than Go/Java/etc. Uber was using JS not TS back then, but the real issue (at least when I started) was lack of a defined interface for the API/mobile app communication. That was eventually addressed by adopting a forked version of Thrift.