That's a trivial challenge. You can rely on things that people are instinctively familiar with.
Look at the current £10 note. To even start on getting a "close enough" material (the feel of the polymer, the clear windows), you're looking at acquiring specialized print stock they don't exactly stock at the Office Supply Warehouse down the street. Now, how exactly are you going to transfer a design to it? Conventional CMYK inkjet and laser-- if you can get it to stick, are going to be a dotty, indistinct mess. Heat-transfer might bake the colour in, but would probably wreck the material and be blurry and smudgy. Once you've figured that out, try to figure out how you can precision-cut and apply holographic foil and optically-variable panels. Now scale it up to the point where it's economically viable.
If you've used a printer before, you know it's not going to be capable of cranking out a convincing banknote.
For consumer acceptance, it's important that people can directly trust the system. I'm concerned that "here's some papers that if I go to my local university, there might be a few experts in the math department who can parse them and tell me it's trustworthy" won't have quite the same impact as "look at the fine lines making up the portrait of Jane Austin, you know that's not coming out of your HP DeskJet."