The cultural devastation wrought on the indigenous peoples of the Americas was tragic. But it was also largely inevitable. The colonization of Africa left many more Africans alive than the colonization of America because America was biologically isolated from Eurasia while Africa was not. The epidemics, particularly of smallpox, that depopulated the Americas were so brutal largely because the indigenous Americans had neither the biological nor the cultural adaptation to infectious disease that was common among Eurasians and Africans. Most indigenous causes of illness in the Americas were due to parasites rather than viruses and bacteria, allowing the evolution of cultural practices like having the entire extended family of a sick person keep them company and try and comfort them through their illness.

One consequence of this is that the indigenous cultures that we’ve actually had the chance to study don’t really represent the pre-Colombian cultures that well, because by then, there was already substantial disruption from the infectious diseases and wildlife that spread throughout the continent well in advance of explorers and colonists.