You can't have interactive elements inside anchor tags. Very often the box will have some additional buttons for different actions, like "Save for later". I like the approach of using an anchor tag just for the title and have another click handler on the box to serve as a fallback, but you don't get to ctrl-click on the box anymore. Alternatively you can have the link be a sibling of the buttons in the DOM, but visually cover the whole box and appear behind the buttons. As you can imagine, any solution like this is going to add more work and be a potential source for bugs.

This is one of the two things that I really wish browsers would fix, instead of cramming in completely new features. The second is how hard is it to make popovers work correctly, especially inside scrollable containers.