I don’t notice any difference between Firefox or Chrome + ublock origin and Safari + Wipr/Firefox Focus.
The biggest benefit is that as every web view on iOS is Safari it means you get content blocking in all apps that use a web view (providing they don't disable it which I'm sure some do but I don't know of any that actually do it). E.g. in the third-party reddit app Apollo any website you load within the app also has all ads blocked.
I paid for full version of AdGuard Pro late last year after my 6 month Android/Oneplus phase ended and I went back to iOS. It has worked REAL well and allows me to just use native Safari. I'm happy with this setup. I used to use free Firefox Focus as the content blocker before, but it would go long time between updates.
The only annoyance with Adguard Pro on iOS (and probably the same for all app based content blockers on iOS) is it is clunky to whitelist a site as they aren't integrated with the browser. You have to open the app itself, dig into the whitelist area and then manually type in/paste the domain name to add it. Brave and FF Focus you can do it right from within the browser, same as it was with FF/ubo on Android.
Also, AdGuard on iOS doesn't acknowledge specific pages only within a domain. For example; mlb.com is loaded with ads, their highlight videos show a 15 sec ad for literally every highlight. I have AdGuard enabled and the experience is so much better. BUT the "Standings" page doesn't load with AdGuard enabled and I can't just disable it only for that page.
Regardless, the small price to pay for AdGuard on iOS is well worth it.
I’m surprised to hear that Firefox doesn’t have the option to do so.
I don’t know if it’s just muscle memory, but Safari on iOS is still my browser of choice due to the way you open and close tabs in it.
Also for Safari, Magic Lasso AdBlocker does a very good job.