That said, I find the show distasteful at times (the use of 'sexposition'), and sometimes it mishandles morality, making it hard to sympathize with any of the characters if you evaluate their decisions objectively. I suspect that like The Wire (and it's probably in that sort of league) it's weakest point will be unrelenting naturalism - constantly trying to show us how terrible and pointless life is, not offering much to aspire to.
But heck, it's mostly just outrageous fun.