At the cost of being practically forced to write your own initramfs, since few of the distro ones actually support this. Surprisingly how few projects use uswsusp anymore...

I think it is possible https://wiki.debian.org/Hibernation/Hibernate_Without_Swap_P...

The default kernel resume implementation will look for a hibernate header in the visible swap partitions on boot.

If you boot into an initramfs and make additional swap partitions visible, eg via losetup, you can then write the device major:minor into /sys/power/resume and kaboom the kernel will freeze userspace, read the hibernation image out of there, then jump to it.