i generally like-ish Laravel, in part because it's PHP so you know it's easy to hack, but...
one potential issue with Laravel is there are 8 trillion pieces of tech you will have to read about or try to ignore to get to a simple deployment.
and even simple deployment is not so simple -- you need tools, lots and lots of tools.
you know, to compile your css. :-D
but i would generally agree-ish with one of the commenters below who recommended Laravel.
it's mostly well done, generally organized, etc.
if you do the current latest install, you'll end up with a Laravel app with a 'Breeze' front end (i think). Breeze being the simpler little cousin of the two 'Jetstream' front ends/routing techs that will also be bundled, but you don't have to use.
The default css is Tailwind, the default templating engine is blade, the default js/component/library implementation is Vue.
laravel also sells - or someone sells - laravel-in-a-box so in theory it's easy to run vagrant-style.
there are now a bunch of 'saas scaffolding' apps out there you can buy for a few hundred bucks - so they give you what every framework should already give you out of the box - authentication, primarily.
and laravel has a trillion plugins/apps/services, some of which are paid. like a deployment service. a fancy admin panel. etc. their own scaffolding, 'Spark', was downgraded to be just a souped-up version of their Cashier plugin/app (I think) - but not sure.
https://www.saaspegasus.com/ is an example for python.
for actual prototyping, if you don't mind learning some app building, low-code services, and don't mind the freemium model with a $50/mo entry fee for non-free level, you could try Anvil or Bubble.
since you know Python i'd look at Anvil first, then Pegasus.