Gut microbial taxa elevated by dietary sugar disrupt memory function
nature.com
nature.com
To the casual observer who doesn't click the link (and just reads the headline on HN), it appears that many articles are Nature articles, when in-fact, they are articles from other journals.
This is published in Translational Psychiatry, which is still a reputable journal by all measures, but it appears to be in Nature by domain alone. The difference between Nature and its sub-journals are quite significant, since Nature is reserved for the "cream of the crop." So, to the casual observer, it may appear as a larger breakthrough than it may be.
I only point this out because I've definitely had the "ooh, a new article in Nature on HN?" reaction, only to be left wanting more because the article isn't a Nature article.
If it was reputable Nature would not do this, they deal in deceit if this is true, deliberately confusing people. I see no reason to trust 'Nature' then, although I'm not even sure what 'Nature' is.
Was it 'Nature' who told us who to vote for? Or do they get to hide behind these facades on that as well?
It's crazy but I used to mock the idea of fasting from a biological perspective (an education emphasis on glucose and misc metabolic pathways to create ATP etc...) because it would make me 'hangry' only to realize that a lot of that was just the crashes from a poor sugary American diet.
Now, its my to go thing to do when I'm feeling ill or lethargic as it perks me up and after nearly a diet of daily intermittent fasting (10-18 hours) I now understand why so many ancient cultures have it as a critical part of their religious practices.
Also, it makes food taste really good as you will savour every bite instead of just stuff your face.
Anyhow, it's insane to me that it took this far into the 21st century for modern medicine to see the obvious when it comes to emphasis of the gut biome in the overall health of the body and mind. The next thing will be the emphasis on healthy animal meat and fats in satiation and lower inflammation, as well as the absurdity of drinking other animals milk with all the antibodies, steroids, antibiotics etc... used in conventional Ag.
Raw milk is ok, but honestly I wonder what the amount of leaky gut and IB, and possibly Crohn's disease this single thing into our diet has caused? It's worth noting that most of the Human population loses the ability to metabolize milk (via na enzyme called lactase) by the time they reach 12, very few populations still have it: think Nordics. Even Mongolians who have been milking animals for 1000s of years still lack this gene/enzyme which.
Probably most of us aren't getting anywhere near as much pectin in our diets as we used to, let alone vegetables.
https://www.reddit.com/r/carnivore/comments/jrl0jg/somewhat_...
Exactly, as a chef we had to match the fashionable diets to our patrons and if you include brussele sprouts to that you essentially lined out the trend veg of the last ~4 years.
I go into ketosis when I need too, and have found that prolonged states of ketosis to be too limiting for an enjoyable life if you love food. BUut I cannot imagine anyone who would simply remove veg from thier diet and believe they're healthy, their is a reason many body builder guys end up with colon cancer and intestine replacements due to an exclusively high protein based diet.
Dr. Zoë Harcombe - What about fiber? https://youtu.be/4KrmpK_Lckg
It does make me wonder if anyone in agriculture/food/health/etc has known about this stuff in private, and for how long if so, like how Exxon did private climate-change studies in the 1970s: https://corporate.exxonmobil.com/-/media/Global/Files/climat...
Yes, Biodynmiac agriculture is just a lot of sound microbiological practices explained with a 'woo' lens which yields amazing food; essentially what the preps are just an inoculation of the microbes found in the Ruminants needed to ensure a healthy flora and fauna at the beginning of a growing season, add this to N fixated crops in rotation with heavy feeders and leaving times of dormancy to repair with grazing Ruminants animals in the off-seasons.
These practices have been in practice since (at least) the beginning of the 20th Century, they started in Austria but took hold in Germany in earnest ever since, and while I think Rudolf Steiner was mainly a grifter, he did create a solid foundation for renewable, sustainable Ag.
Source: Me, a cellular and molecular biologist that undertook a Biodynamic horticulture 'Master Gardener' apprenticeship in Europe. Then managed a Biodynamic farm in Hawaii.
Also, I'd argue most European and Asian cultures have fermented foods that span millennia that reflect the need to maintain a healthy gut biome with tasty food like kimchi or sauerkraut, tsukeomono, too.
I believe this was addressed to me?
6 hour eating windows per day where I eat upwards of 3000+ calories if I'm doing a normal no so extraneous project (tech) with just 3 day gym work outs--1 heavy day between 2 normal light workouts.
If I'm doing manual labour (farming, kitchen, mechanical stuff etc...) which I recommend everyone to do, I'll open it up to two 3 hour windows, between 1pm-4pm, and then 1am-4am. I found this is gives me the most benefit IF i have to eat more calories. If I need to travel while I'm doing any of that I'll go to ketosis and just introduce lots of animals fats and shift to no carbs, I usually don't stay in that state for more than a week, it's too boring and I get tired of eating things like avocados, bacon, eggs and salads really quick now.
Usually when I work manual labour I suffer from a sort of fatigue if I eat in the morning so I've worked around that--I hated waking up in the morning and being forced to eat as a kid so I came to loathe breakfast. So, I'll break my eating windows to 2 ~2500 calorie windows.
But to be honest I've been known to do 4000+ calories in the height of the growing seasons in Spring/Summer/Fall (in my 20s) where I could eat a dozen eggs (raw or cooked) alongside a full size meal with heavy carbs followed by an hour nap. This kept me going until 1am which is when I'd have time to eat again and have a shower and have personal time.
Also, I'm not a heavy guy my normal walking weight is 155 lbs with ~10% body fat, but I have a very fast metabolism so it's like having a turbo V10; sure you can coast it and try to get within a decent MPG, but when it's doing what it was designed to do I can literately feel the heat dissipation from my head from the calories that I'm burning in real time--I was the guy with the steamy head under a hat when it was below zero outside in Germany or Switzerland.
In short I have a harder time not being calorie deficient if I have to put my body to work so I'm unique in that respect even now that I'm over 30. I'm actually only realizing what a gift this is now since I always wanted to be pack on more weight when I was younger.
Emerging evidence highlights a critical relationship between gut microbiota and neurocognitive development. Excessive consumption of sugar and other unhealthy dietary factors during early life developmental periods yields changes in the gut microbiome as well as neurocognitive impairments. However, it is unclear whether these two outcomes are functionally connected. Here we explore whether excessive early life consumption of added sugars negatively impacts memory function via the gut microbiome. Rats were given free access to a sugar-sweetened beverage (SSB) during the adolescent stage of development. Memory function and anxiety-like behavior were assessed during adulthood and gut bacterial and brain transcriptome analyses were conducted. Taxa-specific microbial enrichment experiments examined the functional relationship between sugar-induced microbiome changes and neurocognitive and brain transcriptome outcomes. Chronic early life sugar consumption impaired adult hippocampal-dependent memory function without affecting body weight or anxiety-like behavior. Adolescent SSB consumption during adolescence also altered the gut microbiome, including elevated abundance of two species in the genus Parabacteroides (P. distasonis and P. johnsonii) that were negatively correlated with hippocampal function. Transferred enrichment of these specific bacterial taxa in adolescent rats impaired hippocampal-dependent memory during adulthood. Hippocampus transcriptome analyses revealed that early life sugar consumption altered gene expression in intracellular kinase and synaptic neurotransmitter signaling pathways, whereas Parabacteroides microbial enrichment altered gene expression in pathways associated with metabolic function, neurodegenerative disease, and dopaminergic signaling. Collectively these results identify a role for microbiota “dysbiosis” in mediating the detrimental effects of early life unhealthy dietary factors on hippocampal-dependent memory function.
Perhaps the path to transhumanism will start at the gut.