We already understand exactly how cells and DNA "work", the problem is methabolic networks are very large and hard to simulate with sufficient certainty.
I must have read your comment differently than you intended, since understanding exactly how cells and DNA work implies that the first cell v1.0 would have divided as intended and that it would not have taken 5 years of painstaking research for v2.0.
From the article, "Of the seven genes added to this organism for normal cell division, scientists know what only two of them do."
Each of us is a n=1 genetic experiment.