Is it wrong to say they look alike? There are just times where there is such commonality in a group due to genetic abnormalities and other factors that descriptions are more a fact than a stereotype.
My point is that there is a difference between stereotyping races/cultures/disabled and indicating highly correlated attributes in individuals with specific genetic/chromisonal abnormalities.
If it's in a useful and tasteful context, discuss away. Otherwise, just don't be a chode.