WoW has the ability to redefine the user interface through keyboard short-cuts, LUA code, and UX changes. There is an active community providing different takes on the UX.
WoW has a built in 'time test' which consists of 'boss' encounters in what the game calls a 'raid'. [1]
In polling characters who were better able to perform during an encounter, there was a strong correlation between "keyboard" users and better performace. Better was defined as able to respond faster and more consistently to changing conditions.
It would be interesting to have Tog have a look.
[1] For anyone not familiar with WoW and its gameplay, a group of 10 or 25 people, of different specialties (game specific; damage doers, healers, and damage takers (tanks)) who coordinate during an encounter with a powerful game character (a boss) by fighting it. Healers are focussed on applying various skills to keep the players alive (they take damage due to various game mechanics), damage doers (dps) use different skills to maximize their damage, and tanks use their skills to keep the game characters focussed on attacking them rather than the other players. After a set amount of time, the game character 'enrages' which basically makes it impossible to kill and it does 10x the amount of damage it normally does. This results in a 'wipe' (all player characters in the group dying).