IMO, Ryan Dahl made two fundamental mistakes in both Node and Deno that make them uncompetitive for simple server-side 12-Factor Apps: 1. No web Gateway Interface like WSGI and Rack, and 2. No DBMS API/SPI like JDBC. Express was supposed to be a Microframework like Sinatra and Flask but developers have to spend most of their time defining a robust web server. Since the http server and app code are tightly integrated, 12-Factor Apps or JSON API Microservices are more complicated than they need to be in Node. The lack of a JDBC-like API/SPI hurts many languages included Node and Rust.
The GIL languages are not performant nor concurrent but they have good httpd/dbms interfaces. All the popular server-side language/runtimes are flawed along some fundamental dimension. Server-side REST shouldn’t be this complicated.