I'd be curious to see ML take this problem. I imagine the examples are limitless, but one that comes to mind might be procedural worlds. Rather than tuning procedural worlds around seed values, what would it look like if we try to get an ML to craft the worlds? Procedurally generated worlds often have that feeling. Things don't make sense, etc. I imagine ML could make some far more diverse patterns that are both interesting and fun.
I'd like to see this pattern of "informed RNG" in a lot of things. Skyrim with NPC patterns to feel a bit more authentic. Etc.
I'm less interested in the classic AI dreams inside games, as it seems far out and less gamey. But our current games with informed RNG? That sounds.. neat.