AZ vaccine is made with a genetically engineered Chimpanzee virus, ChAdOx1 . It makes me uneasy. Zoonotic viruses tend to be more dangerous the closer related the species. There's plenty of human viruses that seem harmless like flu except for rare cases where they kill. How do we know that ChAdOx1 is not one of these?

I would be less worried if they used a fish virus or something. My primary concern is using a virus from such a closely related species. The mRNA approach without a live virus seems safer