In this spirit, Samuel Colt is responsible for the death of millions upon millions. Nonsense.
And Alfred Nobel (TNT). His prize notwithstanding, but TNT has unlocked significant natural resources that have improved the quality of life worldwide.
"I am become death. The destroyer of worlds."
A bit of research reveals I was wrong in my assumptions, though, and the Armenian genocide certainly counts by that metric.
In terms of genocide, it was the first one to use computers. It used systematic, organizational principles similar to what a business might use. It created a set of processes both to carry it out and to make the population accept and even participate in the unspeakable.