Wait, so what effect does potential RNA instability really have?
(This is one of the reasons they have very specific handling rules and throw out vaccine that is improperly handled)
> Welcome to Moderna. We believe mRNA is the “software of life." Every cell in the body uses mRNA to provide real-time instructions to make the proteins necessary to drive all aspects of biology, including in human health and disease.
What's the metaphorical software equivalent of "mRNA instability": undefined reference, memory corruption, incomplete download, installation failure, program crash, ...?
Mitochondria won't decode the corrupted mRNA and it will be broken down into constituent parts that are reused by the body.
Edit: Oops, ribosomes, not mitochondria.
(The actual estimate is 10 million billion...)
Edit following my other edit: each cell has something like 10 million ribosomes.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791314/
> Given the central role of RNA in many fundamental biological processes, including translation and splicing, changes to its chemical composition can have a detrimental impact on cellular fitness, with some evidence suggesting that RNA damage has roles in diseases such as neurodegenerative disorders. We are only just beginning to learn about how cells cope with RNA damage, with recent studies revealing the existence of quality-control processes that are capable of recognizing and degrading or repairing damaged RNA.
“This shitty app doesn’t work. Uninstall.”
That’s about it here.