Right now that market is congested with titles, and to break through the noise you would have to substantially raise scope and provide more content and IP(story, characters, elaborate level design, etc.) or more features(multiplayer, level editor, additional game dynamics like the RPG elements of Puzzle Quest et al.)
If you want to break through without raising scope, look for a niche that hasn't been well-covered, and prototype it a few times until you hit on one with a good dynamic.
For example, matching plus tower defense. Will it work? The examples I've seen are few and do it in the crudest way(minigame + minigame - never a recipe for success). Find a way to change their mechanics so that they integrate better, and you might strike gold. Even if you fail, you'll still accumulate design ideas that can be fed into the next game.
Maybe try to put something more significant inside the blocks, like a sci-fi theme (birds and pigs are popular too I hear :)
Fun to play.
Think about all the times ideas like million dollar homepage and pet rocks pops up. People are quick to judge but never seem to see that what they think will succeed or fail is purely an opinion. You can't predict whether something will be a success or not for others.