Firefox (3.6) seems to have a really nasty problem in its garbage collection system. If I leave it open for more than a couple of days, under normal use, it starts hanging for a couple of seconds every minute to half-minute -- and it hangs for longer, more often, the longer I leave it open.
Closing and restarting Firefox seems to clear the issue up. At least, for a while.
The only reason I still use Firefox is because of AdBlock Plus. The moment someone comes up with a replacement that's as good, I'm done with it and never looking back.
edit: oh, and by the way: this bug, combined with Google "Instant"? Very not the best thing ever.