While there was never a commercial S100 board with a 486 on it, this article shows how it is fairly easy to design and build one.
S100 predates the PC bus, which largely replaced it. The AT (a.k.a ISA bus) was a 16-bit version of the 8-bit PC bus. IBM tried to get everyone to switch to the MCA bus, but the high royalties they charged meant that pretty much everone stuck with the AT bus until PCI came out. In its server form of PCI-X, PCI maxed out at 64-bits and 133MHz (though 32-bits and 66MHz was what you would see in a PC), and was replaced by PCIe, which is still used today.
Graphics cards were treated specially at several points along the way, with the VL-bus, and AGP basically being ISA and PCI respectively with dedicated higher-throughput buses to avoid having to use the more expensive MCA and PCI-X when the graphics card was the sole device in the system that needed higher bandwidth.
There was also EISA which was quite popular as an alternative to MCA until PCI bedded itself in.
https://en.wikipedia.org/wiki/Extended_Industry_Standard_Arc...
I particularly enjoyed this (possibly apocryphal bit):
"when it became clear to IBM that Micro Channel was dying, IBM licensed EISA for use in a few server systems."
ISA, EISA, VLB PCI, PCI-X, AGP
I do seem to recall for a short period of time there were some motherboards with both PCI and AGP slots for those who really needed that level of interoperability.
Also there was Extended ISA (EISA) which was a standard promoted by PC compatible manufacturers to compete with MCA. It added 32 bit support and bus mastering to the ISA bus. I and 16 bit ISA cards would still work in an EISA slot. It never really caught on for desktops but briefly had wide support in servers.
This means effectively an x86 style cpu can be part of a simple computer design
[1]http://www.s100computers.com/My%20System%20Index%20Page.htm