"So would you care to give some examples of what McKenna's said that will 'set the agenda of humanity for the next 500 years' and explain your reasons for thinking they'll do so?"
So it's very difficult to do this because most of the ideas he espouses aren't really his. I think his main contribution was in combining a wide range of ideas into a compelling worldview.
- His ideas about the fragility of scientific knowledge, its dubious epistemology, e.g. the importance of the anomalous.
- His ideas about the unsustainability of consumer civilization
- His ideas about the epistemological implications of DMT and psilocybin, and drugs in general
- His ideas about using drugs to discover new ideas (IIRC in this talk: http://www.matrixmasters.net/salon/?p=328)
- His ideas about the singularity and teleology
- His idea about drugs have shaped human culture over the millennia, and possibly also human evolution.
- His focus on the big questions like who are we, why are we here, where are we going, etc.
- The way he was able to find elements of validity in paradigms that have long been outright discarded such as shamanism, alchemy, various spiritual traditions, etc.
It's unclear what impact McKenna will ultimately have because it's hard to predict how people will react to living in a world that's running out of material resources, a world with 100x as many academic studies as there are now, a world with unimaginable technology and suffering, etc. But based on how things seem to be going, it's really hard to see how science can remain indefinitely divorced from philosophy and the humanities, which is sort of the essence of his worldview.
It's difficult to see him ever getting credit for much because his ideas would definitely need to be cleaned up by others and reformulated before having a wider impact, and so it's unclear how he would be credited since most aren't really his ideas to begin with. But I still think a lot of the many of the things he espoused are going to be increasingly more important in the future than they are today.