I can tell you as a gay man I appreciate when people ask about my partner (gender neutral) versus default to wife. Am I offended by it? Not really, it's right 90% of the time. But it's nice that people are considerate of other options when they don't know themselves. And you don't know that I'm gay by looking at me. Many women you do know they're not a man, so you would already know that you're using the male pronoun as default for all people when you could be more contextual to the situation (and avoid pulling the entire history of male-dominated societies and language with it).