If you haven't tried out AdGuard Home, I can highly recommend it. Has same feature set as Pi-Hole and support DoT as well. It's also super trivial to install since it's just a Go binary. Have been using it for ages now and love it!
I have encountered multiple times (not common, but not trivial) that a filter blocks something wrong. With traditional ad-blocker as extension, I can quickly find it out by using build-in logger, and then simply either temporarily disable them or add the site to whitelist with a single click (if I feel like it, I can write my own rule too.)
If I have to change my DNS setting everytime this happens with these DNS-based blockers, I feel like to stick with extensions since I don't really use my phone to browse Internet too much.
The only problem is browsers like Chrome that are pretty aggressive with DNS caching.
I found that, after tinkering with blocklists for a bit, I turned off logging altogether and just let it run. The one thing that gives us grief occasionally is (unsurprisingly) tracking links from promo emails and social media. These are usually easy enough to bypass, but it can be a pain for non-tech-savvy people.
Does it have "cosmetic filters" (the ones that block certain elements on page) or similar feature?
AGH already supports adding AdGuard filters, but for obvious reasons it only applies domain based filters. Adding the MITM proxy would allow for processing of the cosmetic filters too.
More info:
I actually discovered it when I wanted to install pi-hole on my mac server and it just wouldn't work besides with the Docker container, which had other issues like not being able to see the client IP that made the request.
Been running AdGuard Home for a couple months now and it's really nice!