The issue is that the vast majority of these ingredients are artificial substitutes for the actual content of a pizza-like-thing that an average consumer might expect. That they are artificial is not in itself inherently an issue (at least to me, although many many artificial additives have been proven to cause problems while manufacturers continue to use them), but the fact that so many substitutions are made all at once in a given product renders any "common" understanding of its health effects effectively irrelevant.

It basically means that you can't compare a pizza made from the basic ingredients that you and I might normally expect to the contents of a hot pocket. Even comparing apples-to-apples, the ingredient list of a DiGiorno's frozen pizza would be wildly different from the basics of a pizza you could make yourself.

Fearmongering over these subjects never helps, but it is fair to raise concern over the unknown effects of the things you consume.

long list = bad

never heard of it = bad

can't pronounce it = bad

thinking = brain hurt