The biggest problem is viral misinformation combined with a focus on people that are "good with Twitter". Someone with a bunch of followers tweets something like "the sun rose in the north this morning" and if you respond "that didn't happen and it couldn't have happened because science" you'll either be ignored, they'll be offended and block you, or they'll start cursing at you and all their tweets will be liked and retweeted.
The reason I used Twitter back in the day was to find out what was happening in the world and to interact with others. These days there are too many that think a big follower count means they can tweet stuff that's wrong.
Then there's the other stuff where you have to see someone called out for calling women brilliant (yep, happened today).
Try as I might, I can't return my timeline to what it was, and I can now go a week without looking at it and I don't miss anything.