- Decreased efficiency
- Even less efficiency with mutant viruses that of course will spread as widely as the first one did, it's just a matter of time.
- Reportedly more frequent side effects.
This is all of course tentative and based on the latest media reports, the public opinion might change in the future as there is more data - but that's what we've got now. Also the German government reserves Pfizer to the most vulnerable groups which creates an impression that AZ vaccine is somewhat flawed in comparison to Pfizer.