One thing you can do is to properly configure your monitoring software.
1. Pick the right alert sensitivity + notification channel: If your app is well-built and never goes down, 30 second checks and getting alerted after the very first failed request works well. However, if another legacy app is unreliable and often goes down for ~5 minutes when making DB backups, configure your monitoring so that you only get alerted when the legacy service goes down for at least 10 minutes.
2. Get phone calls for high urgent alerts (e.g. homepage is down)
3. Push notification/Slack message for low urgency alerts (e.g. background processing queue has too many tasks enqueued). If you're at a dinner with friends and you get a low-urgency alert you can just ignore it.
4. Don't take it too seriously! Odds are it's not a life/death situation when your app goes down. Downtime happens to everyone!
5. Pick a reliable uptime monitoring provider so that you never get a false incident at 4am in the morning (shameless plug! :)