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In the UK at least, the rooms in all major budget hotel chains are almost identical reagrdless of location. I have stayed in many and, as reguler travellers may agree, it's normal to wake up and not be entirely sure which location you're currently at.

I can confirm, from personal experience at least, that it makes little difference - the first night is always difficult in terms of getting a good night's sleep.

Or what about sleeping in an RV, parked at different locations each night.

I don't know about you, but I shut my eyes when I try to sleep! Sensory stuff is likely to be more subtle, mostly subconscious things like differences in the mattress, ambient temperature, smell etc and your brain probably stores the fact you navigated to a different place somewhere.