That's fair. I wish we had more properly selective COX-2-only inhibitors, despite the scare about heart issues. I may misunderstand how inhibiting COX 1 would balance that out, but I'd be surprised if it does. Many herbs are selective to COX-2, it's like every polyphenol and its mother seems to inhibit it.

I looked and you are correct, I did not realize that acetaminophen was not considered an anti-inflammatory. It certainly is antipyretic, and it appears to have some selective COX-2 activity and some potentially mysterious endocannabinoid activity, which I'd personally consider to be anti-inflammatory in one way. That's truly puzzling, I felt I knew that space decently well due to looking into the inflammatory pathways due to MCAS, I stand corrected on the generally public perception of acetaminophen.

Hopefully endocannabinoid-class drugs and supplements will enter the mainstream/be developed in a generic, OTC fashion with the easing of perception and laws in cannabinoids. I legitimately wonder how much OTC medication has been held back by analog similarities to the (currently and previously) federally illicit substances in those plants.

All good stuff around, I stand corrected and my apologies for any curtness. Have a good one!