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A number of years ago I ditched mice for a Logitech Tracman and it made a lot of difference in how my wrists felt each night.

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I tried different trackballs but ended up using cheap vertical mice, helped a lot with shoulder pain

The Logitech MX Vertical is the GOAT mouse for these issues, IMO. I picked one up when my Microsoft Sculpt gave up the ghost, and I can't imagine ever going back.

The Scuplt was about halfway to a vertical mouse; the MX Vertical is like, all the way there. It was disorienting at first, but I stuck it out for the first weird day or two and I can't say I've ever been happier with a mouse.

This company is dedicated to vertical ergo mouses, they offer some pretty neat features: https://evoluent.com/

I tried most top rated vertical mice, mx included, and ended up with delux wired one. My advise is to try them all before finding one that fits your hand

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