OS/400, and to a lesser extent the B5500 and successor machines, went down that road too. That model was "everything is a relational database." OS/400 had a 20 year run; released in 2008, end of life in 2018.
Other ideas that never really caught on include hardware key/value stores, or "Smart RAM". That may come back, since accessing non-volatile RAM through disk drivers is inefficient.
The talk seems mostly focused on GUIs, which is a separate issue.
If you want to think about a new generation of operating systems, think about what to do in the GPU space. That's the future of hardware. Single CPUs have hit the wall on speed, but there's plenty of room for GPUs with more functional units.
GPU programs are almost stateless. Very functional. But at some level you need state. How should that interact with a near-stateless GPU? Big unsolved problem.