Anecdotal but we left centos for debian because it kept failing after kernel upgrades (machine would not come back / kernel hang: we had it so many times that we migrated completely off it): never had that issue with debian (or ubuntu) and I use both fulltime on servers and desktops (laptops). We had other issues with broken deps with yum as well.

I think GPUs might be a different story but we have not needed those beyond the trivial usage, and those were not discrete.