For me personally, the biggest thing holding it back from becoming a daily use computer is the lack of a really good web browser. WebPositive has made great strides as the native browser, but it still has a long way to go. There are ports of other mainstream browsers but most are incomplete or unstable.
I sorely miss the era around 2000-2001 where I used BeOS successfully as a daily machine, able to browse the Web, access email, do document management and creation (word processing and spreadsheets), photo editing, music production, and video editing all with native-to-BeOS software. It transformed my Windows 98 machine from a slow, clunky, stuttering mess into a computer that felt like it was from the future. Nothing since has come close to that level of technological Nirvana.