Great question. Our general approach is to look up the devtools browser extension for the framework, and use that as a reference point for determining how to interface with the framework

The most popular framework we haven't implemented support for yet is Angular. (AngularJS, the old version, is straightforward.) Any of the compiled frameworks, e.g., Google Closure Compiler are difficult because they mangle identifiers. I suspect Svelte might also be tricky, but we haven't tried that yet

At the end of the day though, every framework has to write to the DOM and be accessible. So you can use selectors, or in the worst case OCR/computer vision. (IIRC, FB actively inserts dummy elements to try to prevent structural scraping).