So you devise an experiment to measure oxygen absorption that uses a probe's existing mass spectrometer. Your experiment doesn't cut into the probe's mass budget so it basically is just a scheduling issue. If your experiment is bumped from the mission schedule there's not compromising the probe or total mission. You've got a pretty good chance of getting that experiment on the docket.
This is contrary to a nutrient experiment that eats into the probe's mass budget and mission time. If the sensors are dedicated to the experiment that's less mass for other sensors. Even if you got approved if you can't built the experiment to be reliable and survivable it won't get approved.
Similar is true for trying to measure CFCs on exoplanets. There's a handful of instruments that can even get spectra from exoplanets and even then only from transiting ones and even then only has giants so far. Even if we could detect CFCs in terrestrial planet atmospheres, CFCs do not stay in the atmosphere very long so you'd only detect them (from a technological civilization) for a very short window of time. The odds of finding them are vanishingly low with current instruments. No one is going to return your e-mails if you propose observations of CFCs because it's a snipe hunt wasting valuable and limited instrument time. If you're a serious researcher you'd know this already and wouldn't waste people's time. Methane is a general purpose biomarker and is something far more likely to be found. Since you've got a limited stars you can even gather information from the time is better spent on the more likely observation.