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Workman(1) might also be worth a try. Supposed to reduce pinky usage, overall finger travel, and balance left/right hand usage, compared Dvorak and Colemak

edit: carpalx(2) is another. I think that was one of the ones generated by a genetic algorithm for key placement?

1) https://workmanlayout.org/ 2) http://pinouchon.github.io/keyboard/layouts/2016/03/07/layou...

Yes to Colemak! Easier transition from Qwerty, more efficient ergonomics, most common shortcuts are the same or similarly positioned! I switched about 14 years ago and so happy I did.

Standard touch-typing advice is to use opposing hands to type combinations like "Shift+A".

On an ergonomic, split keyboard this might be less important: the modifier keys are often under the thumbs, and on both sides.

Also, it's fairly easy to program the keys however you like, e.g. make a "Fn" key, so Fn+DvorakQ sends Ctrl+X.

To support this, you might be interested by this little article: https://github.com/bclnr/kb-layout-evaluation