It seems that as systems scale (in size) they tend to become inherently lower-trust. Consider a physician who makes house calls (not uncommon as recently as a few generations ago, and certainly not incompatible with modern medicine) and a large medical system such as Kaiser Permanente or NHS.
The economic benefits of the larger-scale system are obvious, and are directly measured, but the economic detriment due to increased transaction costs (derived from decreased trust) are neither obvious nor readily measurable.
Upsides of systems at scale can still outweigh downsides, and often do, but I suspect many industrial systems have a maximum scale above which efficiency gains lose out to, in this author's framing, transaction costs.
This abuts certain natural "borders" for system growth, such as national (or in the case of EU, common market) boundaries.