You've likely given up much more than 10-25% by using AWS in the first place (note to the false dichotomist: this doesn't mean owning your own servers). And paid a premium for the privilege.
If you're CPU-bound, get a E-2288G (or whatever the commodity chip that maximized price/$$ is right now) and set mitigations=off.
But if price or performance or user privacy is a concern, none.
I'm a big believe in dedicated hosting. There's tens of thousands of options. Not affiliated with any, but in the past/present what I have/am using and would recommend: webnx.com, reliablesite.net, hivelocity.com, hetzner.com, ovh.com (and their other brands), leaseweb.com we're currently considering phoenixnap.com for a warm-standby DR site (but no experience with them yet). Also, Softlayer pre-IBM acquisition, but that's just sour grapes.
https://www.hetzner.com/dedicated-rootserver/matrix-ax
They have a good reputation for stability too, unlike (say) Scaleway. ;)
I think they end up close to same price/performance as the Intel offerings as well once you invoke the compiler optimiser. The main benefit is better core scalability and lower energy usage which may work out as a net gain for database workloads.
As always it’s best to measure these things yourself with your expected workload.
But you're right in that in the end it all depends on your workload.
Edit: T4g's are available on EC2.
Waiting for the t4 instances.
https://aws.amazon.com/blogs/aws/new-t4g-instances-burstable...