That way you still get sort-ability, you get 16 bit more entropy, fare better on 32 bit systems, and still get 130 years of usage, out of them.
Also you actively discourage people from trying funny stuff like synchronisation and conflict resolution via the time component. Because 1ms "that sounds kinda good enough :?", while 1s "that'll never work!!!"
Ammendment:
Thinking about it. Using a 16bit timestamp prefix with second resolution and rollover should probably provide a good tradeoff between improving insertion performance (most expensive in terms of index touching), a 112 bit random value, and a dense usage of the timstamp field.
It also allows you to do thing like "forgetting" old values, within a 18h timeframe.