Yes, maybe this is just me, but every time I have an extended work from home period, depression follows after a few months.

I was working around this once by drinking red bull, which I found lifted my emotions temporarily, but after it wore off in 4 hours I crashed way harder into despair. This effect built up over time and fortunately I noticed it and stopped using it routinely.

YMMV - just a friendly warning of how it affected me.