If you have vacation time to burn or unlimited PTO, take it. I was surprised how many people won't take time off because they can't go anywhere. As a big fan of staycations, I recommend them. Hide your work laptop for a week and just relax.
Being indoors in a one bedroom apartment makes you crazy.
I admire people who took vacation alone and enjoyed themselves. I had many plans for which I completely lost motivation.
Another vacation tip is to take your vacation across weeks (Wen to Tues). That way you have short work weeks (2 or 3 days) around the vacation.