My desktop is a Threadripper 2990WX running FreeBSD-current with Nvidia graphics.

Its pretty usable as a desktop. I recently switched from KDE/Plasma5 to LXDE, mostly to avoid rolling-release related churn. Eg, I don't want my UI to change everytime I update firefox.

I tried and failed to use it for Google Meet quite a while ago. The problem I had was something to do with the AMD USB chipset. I need to try it again.

What doesn't work natively is anything with DRM. There are workarounds, like running Linux chrome in a linux jail (think WSL), or running spotifyd for Spotify.