There are a range of time zones changes and non-changes. From three consecutive races in UTC+2 (Belgium, Netherlands, Italy in F1 this year) to large changes (Australia, Brazil, Saudi Arabia). The sample size can go beyond the 20 F1 drivers by including junior leagues (F2/F3) as well as MotoGP and other tournaments.
Some F1 teams, like McLaren, are already doing some interesting work outside of car performance which could have benefits outside of motorsport.[1] See MindMaze for work in neuroscience.
Separately, it would also be interesting to test non-drivers like pit stop crew and race strategists. Like drivers, their performance (albeit less/not athletic) can be measured against a stopwatch.