I have to say I have literally never once had the thought that Dropbox is in my way. I have a 3TB pro account which I have setup on my studio computer with full sync to an external drive. I record/work on sessions with sync continually active. Both of those things should be "no no"'s, but it works fine.

I go home and my laptop is smart syncing the recently active sessions only which conserves space on the laptop drive but lets me do some small work on recently active sessions.

It's totally seamless and I cannot recall the last time I was even alerted by Dropbox about anything except that I was hitting my 3TB cap soon.

The only issue I ever had was using it on Windows where it would occasionally create conflicted file copies, which was annoying, but moving to OSX resolved that.