Xi'an (China), along with the other ancient capitals of China (or what we would call China, today).
Other areas around Asia that were inhabited by the Mongols, Manchu/Jurchen, and other related groups. Separately, I'd also like to see the parts of Viet Nam, Cambodia, and Laos where Hmong people live.
Parts of India, such as Arunachal Pradesh because of the diversity and history of people living there (Tai, Monpa, Naga).
Locations that were formerly part of the Assyrian Kingdom along with areas from the Akkadian Kingdom.
Bisbee, Arizona is also somewhere I'd like to stay for a month or so. I've heard it's a fun artists town with funky bohemian vibes.
Finally, my partner has never seen Maine so I'd love to take them to Acadia and then take the ferry over to Newfoundland.
I'm in my 20s female traveler and would probably be traveling alone, most likely sleeping in the back of my SUV- which I've done all over the country and generally in sketchy areas I'll get a hotel room or rent a real campsite.
In terms of safety, it's not a place where anyone "looking for action" is going to hang out. It's a long way from anywhere and even at peak capacity mostly empty. That's my take on most wilderness areas in the US and the only locals at Big Bend are in Boquillas and dependent on a good tourist experience.
All with the caveat that I'm an old man not a young female.
Anyway, the biggest dangers are the usual suspects: exposure, dehydration, and falls. It's remote and dry with temperature extremes. The average worst event is a flat tire from taking Old Maverick Road without truck tires on your vehicle.
If you stick to camping, motel, or car camping in Chisos basin then you're probably good. There are wild havalinas which are mini-pigs that will root around at night, not dangerous.
Unfortunately it is privately owned and its kinda hard to register for a visit.
Also, I have half a mind to visit Paratay, Brazil. All I know is the song Paratay by Mia Doi Todd (1), but as I listen to the lyrics, that's enough to get my wanderlust stirring.
That would make an nice amateur radio Islands On the Air (IOTA) expedition.
Zanskar, Leh - In Ladakh, Northern India, the grand canyon of asia. Ideally for a kayaking trip! http://www.purelandexpeditions.com/
In general I'd like to spend more time checking out the lesser traveled parts of France, Germany and the UK.
Safety wise, if you are afraid of bears you need to be confident enough to handle flares, a large handgun and a large calibre hunting rifle. There are alot of bears, I saw three while I was there though none were close to major settlements.
We did get shown sole CCTV footage from the dock where a bear came down and broke into and ate a crate of frozen whale meat off the dock, that was fun.
Oh and take or get a Greenland dog from one of the kennels to go with you anywhere - they can tell when a bear is near. They aren't pets though, don't expect them to behave like a lapdog.
If you like beer be prepared to take quite some money for it.