You don't have control over your SEO results as well - but you can also measure against SEO traffic with a high degree of certainty.
All big companies do this.
Sure, you're never going to know exactly how many people you advertised to would have organically, eventually found your product and bought it.
But that honestly doesn't seem that important compared to the other metrics - which most functioning large companies have decent data on.
You're also never going to know how many of your customers ate Green Eggs and Ham for breakfast. It's irrelevant. You have decent insight into your direct-online ROAS, and that's unique to direct online advertising, and it's important!!
Yes, you're never going to know if that million dollars you invested in online ads was the best use of that million dollars. But that's not much different than building a new factory, either.
Edit:
Specifically to Uber's case - they did NOT turn off 66% of ALL ads randomly to no adverse effect (implying that all ads are worthless).
They DISCOVERED that a certain type of ad (paying for installs on dubious ad networks) was mostly fraud. After turning off 100% of this type of ad - they found no adverse effect.
This is a fail on their analytics team. They should've been measuring this type of ad better - especially given how big a portion of the total spend it was - and had insight into something not being right. They should have been able to do this - and if they couldn't, because the network somehow didn't give them enough data to do it, they probably shouldn't have been spending this much money for exactly these reasons!