If you're interested in other methods of using Clojure but without Clojure JVM (or JavaScript), check out Babashka: https://github.com/babashka/babashka "native fast-starting Clojure scripting environment"
I realize now that fleck (https://github.com/chr15m/flk) also doesn't even do destructuring and more. Finally the README in the bottom has "You might also be thinking of babashka which is a bare-metal solution using real Clojure".
Babashka is also not slow but rather fast (in startup time).
So, I already did code in clojure before this... the main reason was just know how a host language works, not pure clojure... clojure has everything you need with two or more functions to resolve (amazing!!!)
And I tried to learn reading clojure.core... but Is very dificult. the project "make a lisp" helps me with this problem.
I will try do something with Babashka or Joker soon.
Thanks!