There was a point in my education where I had mastered my trusty TI-83; I knew the purpose of every single function and how to use them. But then, I started running into problems in the real world that required more than 32 KB of memory to solve. When I moved to a laptop I had to relearn all of that knowledge again. Haven't touched my TI-83 since.
It would be nice if the tools we learned how to use in school could also be useful in solving our problems after we graduate!