It’s difficult to go up against someone like Penrose as he’s evidently a genuine genius, I’ve huge respect for the guy, but nobody on Earth knows how to build a strong general AI. That means nobody really knows the details and trade offs of its function, genius or not. So really it comes down to whether you’re a materialist or a dualist, whether you think Intelligence and/or consciousness are physical processes or not. Even if quantum mechanics is a necessary element, it’s still a physical process and quantum computers are a real thing.
But then again, I subscribe to the idea of philosophical zombies. https://en.m.wikipedia.org/wiki/Philosophical_zombie
I mean it's completely possible we are living in a simulation, but the idea that there can be infinite nested simulations or that we could simulate our own universe seems unlikely. I mean think about a program that runs a copy of that program recursively, you'd run out of memory. Now I am aware that some argue that we could be ancestor simulations which would only render what we same like in gaming, BUT! that would mean they would have to simulate billions of minds and a world with physics and fidelity as convincing as our own which would take an insane amount of energy that I can't imagine anyone wanting to do.
If we are a simulation then reality is much more complex than our own.
[0] https://www.seeker.com/tech/physicists-prove-that-reality-is...
edit: https://en.wikipedia.org/wiki/Kernel_same-page_merging
edit: The mentioned security risks in the wikipedia-article could also explain what we call supernatural phenoma, by partially leaking code and/or data between different virtual instances(universes), thereby fucking with our simulated minds :-)
In other words: APOCALYPSE WOW! Again, not as in the end of the world, but in the literal meaning: lifting of the veil.
Happy New Year! ;-)