As soon as self-driving cars become a regular part of people's lives and not an exciting new thing, the calculation will shift to a much more rational one
With autonomous cars, even once you have a few years of safety data from a large enough number of cars to be able to make the call of them being 5x less dangerous than human-driven alternatives in that data, you will still end up having much more "unknown unknowns" (of which I can't tell you any, because they are by design unknown) in addition to also having much more "known unknowns" like the possibility for large-scale software bugs potentially causing thousands of casualties at the same time. These risks will only go down slowly with enough time, there's practically no way of fast tracking getting these down, hence you have to incorporate a large enough risk buffer in your assumptions for rationalizing to even start using that fancy new tech, and the only place where this risk buffer can come from is having a much bigger difference in the "known knowns" department of risks.
Nothing. That's why regardless of how impressively big these test fleets are, there will be a lot more of these unknowns.
However, how many people get hurt is not the only thing that needs to be considered. It's very likely that when a self-driving car would be equally safe as a human driver, the people who die in accidents caused by the car would be different than those who would die in accidents caused by human drivers, and so you'd end up with situations where individual next-of-kin could make entirely legitimate claims after accidents that their loved ones would be alive if not for the hellspawn car.
Trying to convince juries that it's alright because for every person who die in the cars, two other people who would have otherwise died got to live would probably be tough. Especially as the accidents that the self-driving cars are most apt to prevent are ones that could at least partially be considered caused directly by bad choices made by the driver (DUI, distracted driving, falling asleep at the wheel).
Once the data gets good enough that you don't need to do statistics on it[0], it becomes a lot easier to sell the idea to the public.
[0]: Relevant xkcd: https://xkcd.com/2400/